Nevertheless, long-term observation is still needed to monitor the side effects of therapy.Īlopecia areata (AA) is an organ-specific autoimmune disease mediated by T lymphocytes targeting hair follicles. The combination of systemic methotrexate and corticosteroids, and topical minoxidil showed promising results in AU.
Performed the hematological examination, liver function levels, blood glucose levels, and cortisol during long-term use of methotrexate and corticosteroids are necessary. Systemic combination therapy of methotrexate and low-dose corticosteroids and topical minoxidil 5% in this patient gave responsive results. However, striae were found after 3rd month of therapy. Observations after nine months of treatment showed an improvement in the decrease in SALT scores to 41%. The patient was given a combination therapy of 15 mg methotrexate per week and 16 mg methylprednisolone per day orally and topical treatment with minoxidil 5%. The patient’s severity of alopecia tool (SALT) score was 100%. Herein, we reported a case of AU in a 19-year-old man with alopecia in the hairy scalp area, eyebrows, eyelashes, moustache, beard, and axillary hair since 2.5 years ago. AU therapy is relatively difficult and challenging with varying outcomes. Severe AA could be in the form of alopecia universalis (AU). Alopecia areata (AA) is an autoimmune disease-specific to specific organs mediated by T lymphocytes with hair follicles as targets.
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